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Target
Falcipain 2
Ligand
BDBM50538770
Substrate
n/a
Meas. Tech.
ChEMBL_1977169 (CHEMBL4610304)
IC50
12160±n/a nM
Citation
 Rana, D; Kalamuddin, M; Sundriyal, S; Jaiswal, V; Sharma, G; Das Sarma, K; Sijwali, PS; Mohmmed, A; Malhotra, P; Mahindroo, N Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50538770
Synonyms:
CHEMBL4637201
Type:
Small organic molecule
Emp. Form.:
C25H23N3O2
Mol. Mass.:
397.469
SMILES:
O=C(NCCCNC(=O)c1ccc(cc1)-c1ccccc1)c1cc2ccccc2[nH]1
Structure:
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