Reaction Details Report a problem with these data
Target
Chromobox protein homolog 8
Ligand
BDBM50538816
Substrate
n/a
Meas. Tech.
ChEMBL_1977193 (CHEMBL4610328)
IC50
12000±n/a nM
Citation
 Milosevich, N; McFarlane, J; Gignac, MC; Li, J; Brown, TM; Wilson, CR; Devorkin, L; Croft, CS; Hof, R; Paci, I; Lum, JJ; Hof, F Pan-specific and partially selective dye-labeled peptidic inhibitors of the polycomb paralog proteins. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 8
Synonyms:
CBX8 | CBX8_HUMAN | PC3 | Polycomb 3 homolog | RC1 | Rectachrome 1 | hPc3
Type:
PROTEIN
Mol. Mass.:
43415.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108272
Residue:
389
Sequence:
MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRAREGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERERGTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGKFPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGALDPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEKVVVTDVTSNFLTVTIKESNTDQGFFKEKR
  
Inhibitor
Name:
BDBM50538816
Synonyms:
CHEMBL4642464
Type:
Small organic molecule
Emp. Form.:
C45H60BrN8O11
Mol. Mass.:
968.908
SMILES:
C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Br)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: