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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM393389
Substrate
n/a
Meas. Tech.
ChEMBL_1977317 (CHEMBL4610452)
IC50
5.7±n/a nM
Citation
 Malamas, MS; Farah, SI; Lamani, M; Pelekoudas, DN; Perry, NT; Rajarshi, G; Miyabe, CY; Chandrashekhar, H; West, J; Pavlopoulos, S; Makriyannis, A Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM393389
Synonyms:
3-((4'-Methoxy-5-phenoxy-[1,1'-biphenyl]-2-yl)methoxy)azetidine-1-carbonitrile | US9963444, Example 90
Type:
Small organic molecule
Emp. Form.:
C24H22N2O3
Mol. Mass.:
386.4431
SMILES:
COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N
Structure:
Search PDB for entries with ligand similarity: