Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50095493
Substrate
n/a
Meas. Tech.
ChEMBL_45557 (CHEMBL656687)
IC50
17±n/a nM
Citation
 Falgueyret, JP; Oballa, RM; Okamoto, O; Wesolowski, G; Aubin, Y; Rydzewski, RM; Prasit, P; Riendeau, D; Rodan, SB; Percival, MD Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem 44:94-104 (2001) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50095493
Synonyms:
CHEMBL276169 | N-(1-Cyano-azetidin-3-ylmethyl)-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C11H13N3O2S
Mol. Mass.:
251.305
SMILES:
O=S(=O)(NCC1CN(C1)C#N)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: