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Target
Cyclin-dependent kinase 5
Ligand
BDBM50526797
Substrate
n/a
Meas. Tech.
ChEMBL_1978726 (CHEMBL4611861)
IC50
9400±n/a nM
Citation
 Diab, S; Yu, M; Wang, S CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success? J Med Chem 63:7458-7474 (2020) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50526797
Synonyms:
Ct-7001 | Ct7001 | ICEC-0942 | ICEC0942 | Samuraciclib | US11857552, Compound REF-001
Type:
Small organic molecule
Emp. Form.:
C22H30N6O
Mol. Mass.:
394.5132
SMILES:
CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCNC[C@@H]3O)nc12
Structure:
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