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Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Ligand
BDBM50242014
Substrate
n/a
Meas. Tech.
ChEMBL_1979331 (CHEMBL4612466)
IC50
28650±n/a nM
Citation
 Heger, V; Benesova, B; Viskupicova, J; Majekova, M; Zoofishan, Z; Hunyadi, A; Horakova, L Phenolic Compounds from  ACS Med Chem Lett 11:1006-1013 (2020) [PubMed]  Article 
Target
Name:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Synonyms:
AT2A1_RAT | Atp2a1 | Calcium pump 1 | Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform | Endoplasmic reticulum class 1/2 Ca(2+) ATPase | SERCA1 | SR Ca(2+)-ATPase 1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Type:
PROTEIN
Mol. Mass.:
109386.62
Organism:
Rattus norvegicus
Description:
ChEMBL_109814
Residue:
994
Sequence:
MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICSLNEFSITGSTYAPEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELLKFIARNYLEG
  
Inhibitor
Name:
BDBM50242014
Synonyms:
CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149 | cid_5281671
Type:
Small organic molecule
Emp. Form.:
C25H24O6
Mol. Mass.:
420.4545
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(oc2c3-[#6]=[#6]C([#6])([#6])[#8]-c3cc(-[#8])c2c1=O)-c1ccc(-[#8])cc1-[#8] |c:10|
Structure:
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