Reaction Details Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50540081
Substrate
n/a
Meas. Tech.
ChEMBL_1980319 (CHEMBL4613581)
IC50
3000±n/a nM
Citation
 Gao, F; Zhang, X; Wang, T; Xiao, J Quinolone hybrids and their anti-cancer activities: An overview. Eur J Med Chem 165:59-79 (2019) [PubMed]  Article 
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50540081
Synonyms:
CHEMBL4438921
Type:
Small organic molecule
Emp. Form.:
C25H24FN5O4
Mol. Mass.:
477.4876
SMILES:
Fc1cc2c(cc1N1CCNCC1)n(cc(C(=O)N\N=C\c1ccc3OCOc3c1)c2=O)C1CC1
Structure:
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