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Target
DNA topoisomerase I
Ligand
BDBM50410161
Substrate
n/a
Meas. Tech.
ChEMBL_1980356 (CHEMBL4613618)
IC50
307000±n/a nM
Citation
 Alsayari, A; Muhsinah, AB; Hassan, MZ; Ahsan, MJ; Alshehri, JA; Begum, N Aurone: A biologically attractive scaffold as anticancer agent. Eur J Med Chem 166:417-431 (2019) [PubMed]  Article 
Target
Name:
DNA topoisomerase I
Synonyms:
5.6.2.1 | DNA topoisomerase 1 | DNA topoisomerase I | TOP1
Type:
PROTEIN
Mol. Mass.:
89735.02
Organism:
Bos taurus
Description:
ChEMBL_119672
Residue:
757
Sequence:
DSSLMVADSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKIKASGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKPKNKDKDKDKKVPEPDSKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKEQLADARRDLKSAKADAKVLKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
  
Inhibitor
Name:
BDBM50410161
Synonyms:
CHEMBL191804
Type:
Small organic molecule
Emp. Form.:
C15H10O2
Mol. Mass.:
222.2387
SMILES:
O=C1Oc2ccccc2\C1=C/c1ccccc1
Structure:
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