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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50540285
Substrate
n/a
Meas. Tech.
ChEMBL_1981462 (CHEMBL4614724)
IC50
3480±n/a nM
Citation
 Massaro, C; Thomas, J; Ikhlef, H; Dinara, S; Cronk, S; Moots, H; Phanstiel, O Serendipitous Discovery of Leucine and Methionine Depletion Agents during the Search for Polyamine Transport Inhibitors. J Med Chem 63:2814-2832 (2020) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50540285
Synonyms:
CHEMBL4642431
Type:
Small organic molecule
Emp. Form.:
C29H51N3
Mol. Mass.:
441.7353
SMILES:
CC(C)CCN1CCN(C[C@@H]1CC(C)C)[C@@H](CNCc1ccccc1)CC1CCCCC1 |r|
Structure:
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