Reaction Details Report a problem with these data
Target
Trypanothione reductase
Ligand
BDBM50096496
Substrate
n/a
Meas. Tech.
ChEBML_225789
Ki
3480±n/a nM
Citation
Li, Z; Fennie, MW; Ganem, B; Hancock, MT; Kobaslija, M; Rattendi, D; Bacchi, CJ; O'Sullivan, MC Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. Bioorg Med Chem Lett 11:251-4 (2001) [PubMed] Article
More Info.:
Target
Name:
Trypanothione reductase
Synonyms:
N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR
Type:
Homodimer; oxidoreductase
Mol. Mass.:
53868.26
Organism:
Trypanosoma cruzi
Description:
n/a
Residue:
492
Sequence:
MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKPSEASL
Inhibitor
Name:
BDBM50096496
Synonyms:
CHEMBL62048 | N,N'-Bis-(3-amino-propyl)-N,N'-bis-(3-phenyl-propyl)-butane-1,4-diamine | N1,N4-bis(3-aminopropyl)-N1,N4-bis(3-phenylpropyl)butane-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C28H46N4
Mol. Mass.:
438.6916
SMILES:
NCCCN(CCCCN(CCCN)CCCc1ccccc1)CCCc1ccccc1