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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50540493
Substrate
n/a
Meas. Tech.
ChEMBL_1981912 (CHEMBL4615174)
Ki
1.5±n/a nM
Citation
 Del Bello, F; Bonifazi, A; Giorgioni, G; Piergentili, A; Sabbieti, MG; Agas, D; Dell'Aera, M; Matucci, R; Górecki, M; Pescitelli, G; Vistoli, G; Quaglia, W Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus. J Med Chem 63:5763-5782 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50540493
Synonyms:
CHEMBL4635500
Type:
Small organic molecule
Emp. Form.:
C19H29NO2
Mol. Mass.:
303.4391
SMILES:
CN(C)C[C@H]1COC[C@](O1)(C1CCCCC1)c1ccccc1 |r|
Structure:
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