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Target
Monoglyceride lipase
Ligand
BDBM50540526
Substrate
n/a
Meas. Tech.
ChEMBL_1982181 (CHEMBL4615443)
Ki
13±n/a nM
Citation
 Zhi, Z; Zhang, W; Yao, J; Shang, Y; Hao, Q; Liu, Z; Ren, Y; Li, J; Zhang, G; Wang, J Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors. J Med Chem 63:5783-5796 (2020) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50540526
Synonyms:
CHEMBL4637658
Type:
Small organic molecule
Emp. Form.:
C23H21ClN2O2
Mol. Mass.:
392.878
SMILES:
Clc1cccc(NC(=O)C2CCN(CC2)C(=O)c2ccc3ccccc3c2)c1
Structure:
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