Reaction Details Report a problem with these data
Target
M-phase inducer phosphatase 2
Ligand
BDBM50096680
Substrate
n/a
Meas. Tech.
ChEMBL_48703 (CHEMBL659778)
Ki
4600±n/a nM
Citation
 Wipf, P; Aslan, DC; Southwick, EC; Lazo, JS Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. Bioorg Med Chem Lett 11:313-7 (2001) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50096680
Synonyms:
(E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-chloro-phenyl)-5-propyl-thiazol-2-yl]-amide | CHEMBL421227
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N2O2S2
Mol. Mass.:
453.405
SMILES:
CCCc1sc(NS(=O)(=O)\C=C\c2ccccc2Cl)nc1-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: