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Target
ATP-dependent RNA helicase DDX3X
Ligand
BDBM50540793
Substrate
n/a
Meas. Tech.
ChEMBL_1982886 (CHEMBL4616148)
IC50
300±n/a nM
Citation
 Brai, A; Boccuto, A; Monti, M; Marchi, S; Vicenti, I; Saladini, F; Trivisani, CI; Pollutri, A; Trombetta, CM; Montomoli, E; Riva, V; Garbelli, A; Nola, EM; Zazzi, M; Maga, G; Dreassi, E; Botta, M Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor. ACS Med Chem Lett 11:956-962 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX3X
Synonyms:
DBX | DDX3 | DDX3X | DDX3X_HUMAN
Type:
PROTEIN
Mol. Mass.:
73247.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811954
Residue:
662
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
  
Inhibitor
Name:
BDBM50540793
Synonyms:
CHEMBL4635553
Type:
Small organic molecule
Emp. Form.:
C22H24F3N5O2
Mol. Mass.:
447.4535
SMILES:
COc1cc(NC(=O)Nc2ccccc2C(F)(F)F)ccc1-n1cc(CCC(C)C)nn1
Structure:
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