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Target
14-3-3 protein zeta/delta
Ligand
BDBM50540835
Substrate
n/a
Meas. Tech.
ChEMBL_1983088 (CHEMBL4616350)
Kd
16000±n/a nM
Citation
 Hartman, AM; Elgaher, WAM; Hertrich, N; Andrei, SA; Ottmann, C; Hirsch, AKH Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry. ACS Med Chem Lett 11:1041-1046 (2020) [PubMed]  Article 
Target
Name:
14-3-3 protein zeta/delta
Synonyms:
14-3-3 protein zeta/delta | 1433Z_HUMAN | KCIP-1 | Protein kinase C inhibitor protein 1 | YWHAZ
Type:
PROTEIN
Mol. Mass.:
27731.18
Organism:
Homo sapiens
Description:
ChEMBL_117504
Residue:
245
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
  
Inhibitor
Name:
BDBM50540835
Synonyms:
CHEMBL4634488
Type:
Small organic molecule
Emp. Form.:
C16H15BrN2OS
Mol. Mass.:
363.272
SMILES:
Brc1cccc(\C=N\NC(=O)c2cc3CCCCc3s2)c1
Structure:
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