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Target
Cytosolic phospholipase A2 gamma
Ligand
BDBM22319
Substrate
n/a
Meas. Tech.
ChEBML_52417
IC50
>100000±n/a nM
Citation
 Seno, K; Okuno, T; Nishi, K; Murakami, Y; Yamada, K; Nakamoto, S; Ono, T Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett 11:587-90 (2001) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2 gamma
Synonyms:
PA24C_HUMAN | PLA2G4C | Phospholipase A2 group IVC | cPLA2-gamma
Type:
PROTEIN
Mol. Mass.:
60942.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_52417
Residue:
541
Sequence:
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSLQKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPEDEGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCLA
  
Inhibitor
Name:
BDBM22319
Synonyms:
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid | Arachidonic acid | Arachidonic acid (AA) | CHEMBL15594 | [1-14C]Arachidonic acid
Type:
Unsaturated fatty acid
Emp. Form.:
C20H32O2
Mol. Mass.:
304.4669
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Structure:
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