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Target
Beta-glucuronidase
Ligand
BDBM316368
Substrate
n/a
Meas. Tech.
ChEMBL_1983556 (CHEMBL4616962)
IC50
20±n/a nM
Citation
 Awolade, P; Cele, N; Kerru, N; Gummidi, L; Oluwakemi, E; Singh, P Therapeutic significance of ?-glucuronidase activity and its inhibitors: A review. Eur J Med Chem 187:0 (2020) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:
Protein
Mol. Mass.:
74736.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
  
Inhibitor
Name:
BDBM316368
Synonyms:
US9617239, BRITE-355252
Type:
Small organic molecule
Emp. Form.:
C25H24ClN3O3S2
Mol. Mass.:
514.059
SMILES:
Clc1cc(sc1Oc1cccc(c1)N1CCNCC1)S(=O)(=O)NCc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: