Reaction Details
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50097634
Substrate
n/a
Meas. Tech.
ChEBML_161777
IC50
7±n/a nM
Citation
Frydrychowski, VA; Urbanek, RA; Dounay, AB; Forsyth, CJ Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A. Bioorg Med Chem Lett 11:647-9 (2001) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_HUMAN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161777
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Inhibitor
Name:
BDBM50097634
Synonyms:
CHEMBL158524 | OKADAIC ACID | okadaic acid analogue
Type:
Small organic molecule
Emp. Form.:
C44H68O13
Mol. Mass.:
805.0029
SMILES:
[H][C@@]12CC[C@@]3(CC[C@@H](O3)\C=C\[C@@H](C)[C@@H]3CC(C)=C[C@@]4(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]4O)O3)O[C@@]1([H])[C@H](O)C(=C)[C@H](O2)[C@@H](O)C[C@H](C)[C@@]1([H])O[C@@]2(CCCCO2)CC[C@H]1C |r,c:17|
Structure:
