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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50097891
Substrate
n/a
Meas. Tech.
ChEBML_2612
Ki
130±n/a nM
Citation
 Laban, U; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Nichols, DE A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties. Bioorg Med Chem Lett 11:793-5 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50097891
Synonyms:
4-Fluoro-5-methoxy-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole | CHEMBL352186
Type:
Small organic molecule
Emp. Form.:
C15H19FN2O
Mol. Mass.:
262.3226
SMILES:
COc1ccc2[nH]cc(CCN3CCCC3)c2c1F
Structure:
Search PDB for entries with ligand similarity: