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Target
Protein cereblon
Ligand
BDBM50541821
Substrate
n/a
Meas. Tech.
ChEMBL_1985380 (CHEMBL4618786)
Ki
2200±n/a nM
Citation
 Kargbo, RB Ligand Design for Cereblon Based Immunomodulatory Therapy. ACS Med Chem Lett 11:1088-1089 (2020) [PubMed]  Article 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM50541821
Synonyms:
CHEMBL4639892
Type:
Small organic molecule
Emp. Form.:
C15H14N4O3
Mol. Mass.:
298.2967
SMILES:
Nc1ccnc2c(cccc12)C(=O)NC1CCC(=O)NC1=O
Structure:
Search PDB for entries with ligand similarity: