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Target
Histone deacetylase 8
Ligand
BDBM50542224
Substrate
n/a
Meas. Tech.
ChEMBL_1986246 (CHEMBL4619652)
Kd
9.8±n/a nM
Citation
 Hassan, MM; Israelian, J; Nawar, N; Ganda, G; Manaswiyoungkul, P; Raouf, YS; Armstrong, D; Sedighi, A; Olaoye, OO; Erdogan, F; Cabral, AD; Angeles, F; Altintas, R; de Araujo, ED; Gunning, PT Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting. J Med Chem 63:8634-8648 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50542224
Synonyms:
CHEMBL4637226
Type:
Small organic molecule
Emp. Form.:
C19H17F3N2O3
Mol. Mass.:
378.3451
SMILES:
ONC(=O)c1ccc(cc1)N(CC1CC1)C(=O)c1cccc(c1)C(F)(F)F
Structure:
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