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Target
Peptide deformylase
Ligand
BDBM50100107
Substrate
n/a
Meas. Tech.
ChEMBL_154313 (CHEMBL762798)
IC50
230±n/a nM
Citation
 Apfel, C; Banner, DW; Bur, D; Dietz, M; Hubschwerlen, C; Locher, H; Marlin, F; Masciadri, R; Pirson, W; Stalder, H 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors. J Med Chem 44:1847-52 (2001) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_ECOLI | PDF | Peptide Deformylase | Polypeptide deformylase | def | fms
Type:
Enzyme
Mol. Mass.:
19323.16
Organism:
Escherichia coli (strain K12)
Description:
The pdf gene from E. coli K12 was cloned and protein was expressed and purified from E. coli BL21(DE3).
Residue:
169
Sequence:
MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLKQQRIRQKVEKLDRLKARA
  
Inhibitor
Name:
BDBM50100107
Synonyms:
CHEMBL53345 | N-Hydroxy-2-(2-oxo-5-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C11H10F3N3O3
Mol. Mass.:
289.2106
SMILES:
ONC(=O)CN1Cc2c(NC1=O)cccc2C(F)(F)F
Structure:
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