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Target
Carbonyl reductase [NADPH] 1
Ligand
BDBM50543399
Substrate
n/a
Meas. Tech.
ChEMBL_1989079 (CHEMBL4622626)
IC50
270±n/a nM
Citation
 Endo, S; Oguri, H; Segawa, J; Kawai, M; Hu, D; Xia, S; Okada, T; Irie, K; Fujii, S; Gouda, H; Iguchi, K; Matsukawa, T; Fujimoto, N; Nakayama, T; Toyooka, N; Matsunaga, T; Ikari, A Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer. J Med Chem 63:10396-10411 (2020) [PubMed]  Article 
Target
Name:
Carbonyl reductase [NADPH] 1
Synonyms:
CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1
Type:
PROTEIN
Mol. Mass.:
30380.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_607770
Residue:
277
Sequence:
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
  
Inhibitor
Name:
BDBM50543399
Synonyms:
CHEMBL4648793
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3
Mol. Mass.:
294.3047
SMILES:
Cc1ccc(NC(=O)c2cc3cccc(O)c3oc2=N)cc1
Structure:
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