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Target
Peptidyl-prolyl cis-trans isomerase FKBP4
Ligand
BDBM50543434
Substrate
n/a
Meas. Tech.
ChEMBL_1989150 (CHEMBL4622697)
Kd
1300±n/a nM
Citation
 de la Sierra-Gallay, IL; Belnou, M; Chambraud, B; Genet, M; van Tilbeurgh, H; Aumont-Nicaise, M; Desmadril, M; Baulieu, EE; Jacquot, Y; Byrne, C Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52. J Med Chem 63:10330-10338 (2020) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:
FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:
PROTEIN
Mol. Mass.:
51793.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154482
Residue:
459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
  
Inhibitor
Name:
BDBM50543434
Synonyms:
CHEMBL4645417
Type:
Small organic molecule
Emp. Form.:
C33H42FN7O6S
Mol. Mass.:
683.793
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Structure:
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