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Target
Collagenase ColA
Ligand
BDBM50100809
Substrate
n/a
Meas. Tech.
ChEMBL_49485 (CHEMBL659907)
Ki
19±n/a nM
Citation
 Clare, BW; Scozzafava, A; Supuran, CT Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type. J Med Chem 44:2253-8 (2001) [PubMed]  Article 
Target
Name:
Collagenase ColA
Synonyms:
120 kDa collagenase | COLA_CLOPE | Microbial collagenase | colA
Type:
PROTEIN
Mol. Mass.:
125901.02
Organism:
Clostridium perfringens
Description:
ChEMBL_49485
Residue:
1104
Sequence:
MKKNLKRGELTKLKLVERWSATFTLAAFILFNSSFKVLAADKKVENSNNGQITREINADQISKTELNNEVATDNNRPLGPSIAPSRARNNKIYTFDELNRMNYSDLVELIKTISYENVPDLFNFNDGSYTFFSNRDRVQAIIYGLEDSGRTYTADDDKGIPTLVEFLRAGYYLGFYNKQLSYLNTPQLKNECLPAMKAIQYNSNFRLGTKAQDGVVEALGRLIGNASADPEVINNCIYVLSDFKDNIDKYGSNYSKGNAVFNLMKGIDYYTNSVIYNTKGYDAKNTEFYNRIDPYMERLESLCTIGDKLNNDNAWLVNNALYYTGRMGKFREDPSISQRALERAMKEYPYLSYQYIEAANDLDLNFGGKNSSGNDIDFNKIKADAREKYLPKTYTFDDGKFVVKAGDKVTEEKIKRLYWASKEVKAQFMRVVQNDKALEEGNPDDILTVVIYNSPEEYKLNRIINGFSTDNGGIYIENIGTFFTYERTPEESIYTLEELFRHEFTHYLQGRYVVPGMWGQGEFYQEGVLTWYEEGTAEFFAGSTRTDGIKPRKSVTQGLAYDRNNRMSLYGVLHAKYGSWDFYNYGFALSNYMYNNNMGMFNKMTNYIKNNDVSGYKDYIASMSSDYGLNDKYQDYMDSLLNNIDNLDVPLVSDEYVNGHEAKDINEITNDIKEVSNIKDLSSNVEKSQFFTTYDMRGTYVGGRSQGEENDWKDMNSKLNDILKELSKKSWNGYKTVTAYFVNHKVDGNGNYVYDVVFHGMNTDTNTDVHVNKEPKAVIKSDSSVIVEEEINFDGTESKDEDGEIKAYEWDFGDGEKSNEAKATHKYNKTGEYEVKLTVTDNNGGINTESKKIKVVEDKPVEVINESEPNNDFEKANQIAKSNMLVKGTLSEEDYSDKYYFDVAKKGNVKITLNNLNSVGITWTLYKEGDLNNYVLYATGNDGTVLKGEKTLEPGRYYLSVYTYDNQSGTYTVNVKGNLKNEVKETAKDAIKEVENNNDFDKAMKVDSNSKIVGTLSNDDLKDIYSIDIQNPSDLNIVVENLDNIKMNWLLYSADDLSNYVDYANADGNKLSNTCKLNPGKYYLCVYQFENSGTGNYIVNLQNK
  
Inhibitor
Name:
BDBM50100809
Synonyms:
2-(N-(2-nitrobenzyl)-4-methoxyphenylsulfonamido)-N-hydroxypropanamide | CHEMBL450327 | N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-(2-nitro-benzyl)-amino]-propionamide
Type:
Small organic molecule
Emp. Form.:
C17H19N3O7S
Mol. Mass.:
409.414
SMILES:
COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1[N+]([O-])=O)C(C)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: