Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM50543887
Substrate
n/a
Meas. Tech.
ChEMBL_1990603 (CHEMBL4624338)
IC50
6.0±n/a nM
Citation
 Banzato, TP; Gubiani, JR; Bernardi, DI; Nogueira, CR; Monteiro, AF; Juliano, FF; de Alencar, SM; Pilli, RA; Lima, CA; Longato, GB; Ferreira, AG; Foglio, MA; Carvalho, JE; Vendramini-Costa, DB; Berlinck, RGS Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis. J Nat Prod 83:1784-1793 (2020) [PubMed]  Article 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM50543887
Synonyms:
CHEMBL4649115
Type:
Small organic molecule
Emp. Form.:
C40H34O10
Mol. Mass.:
674.692
SMILES:
CC(C)(C=C)c1cc(C(=O)c2c(oc3cc(O)ccc23)-c2cc(c(O)cc2O)-c2cc3cc(c(O)cc3oc2=O)C(C)(C)C=C)c(O)cc1O
Structure:
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