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Target
Monoglyceride lipase
Ligand
BDBM50543935
Substrate
n/a
Meas. Tech.
ChEMBL_1990831 (CHEMBL4624566)
IC50
10.0±n/a nM
Citation
 Zhu, B; Connolly, PJ; Zhang, YM; McDonnell, ME; Bian, H; Lin, SC; Liu, L; Zhang, SP; Chevalier, KM; Brandt, MR; Milligan, CM; Flores, CM; Macielag, MJ The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50543935
Synonyms:
CHEMBL1615314
Type:
Small organic molecule
Emp. Form.:
C25H30N6O2
Mol. Mass.:
446.5447
SMILES:
O=C(N1CC(C1)N1CCN(CC1)c1ncccn1)c1ccc2nc(oc2c1)C1CCCCC1
Structure:
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