Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM50544057
Substrate
n/a
Meas. Tech.
ChEMBL_1991430 (CHEMBL4625165)
EC50
400±n/a nM
Citation
 Cornelison, JL; Cato, ML; Johnson, AM; D'Agostino, EH; Melchers, D; Patel, AB; Mays, SG; Houtman, R; Ortlund, EA; Jui, NT Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM50544057
Synonyms:
CHEMBL4637563
Type:
Small organic molecule
Emp. Form.:
C28H39N3O2S
Mol. Mass.:
481.693
SMILES:
[H][C@@]12CC(CCCCCC)=C(c3ccccc3)[C@]1(CN(C)c1ccccc1)CC[C@@H]2NS(N)(=O)=O |r,t:9|
Structure:
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