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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50101172
Substrate
n/a
Meas. Tech.
ChEMBL_71605 (CHEMBL689137)
IC50
3±n/a nM
Citation
 Ashton, WT; Sisco, RM; Yang, YT; Lo, JL; Yudkovitz, JB; Cheng, K; Goulet, MT Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett 11:1723-6 (2001) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50101172
Synonyms:
CHEMBL49578 | N-[4-(4-{2-[5-(7-Aza-bicyclo[2.2.1]heptane-7-carbonyl)-2-(3,5-dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C36H44N4O3S
Mol. Mass.:
612.825
SMILES:
Cc1cc(C)cc(c1)-c1[nH]c2ccc(cc2c1CCNCCCCc1ccc(NS(C)(=O)=O)cc1)C(=O)N1C2CCC1CC2 |TLB:35:37:39.40:43.42|
Structure:
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