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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50544141
Substrate
n/a
Meas. Tech.
ChEMBL_1991789 (CHEMBL4625524)
Ki
104±n/a nM
Citation
 Karki, A; Namballa, HK; Alberts, I; Harding, WW Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50544141
Synonyms:
CHEMBL4639400
Type:
Small organic molecule
Emp. Form.:
C22H26N2O2
Mol. Mass.:
350.454
SMILES:
COc1cc2CCN(C)C3Cc4ccc(N)cc4-c(c1OCC1CC1)c23
Structure:
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