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Target
6-pyruvoyl tetrahydrobiopterin synthase
Ligand
BDBM50544440
Substrate
n/a
Meas. Tech.
ChEMBL_1992578 (CHEMBL4626313)
IC50
>30000±n/a nM
Citation
 Ruddraraju, KV; Aggarwal, D; Niu, C; Baker, EA; Zhang, RY; Wu, L; Zhang, ZY Highly Potent and Selective  J Med Chem 63:9212-9227 (2020) [PubMed]  Article 
Target
Name:
6-pyruvoyl tetrahydrobiopterin synthase
Synonyms:
4.2.3.12 | 6-pyruvoyl tetrahydrobiopterin synthase | PTP synthase | PTPS | PTPS_HUMAN | PTS
Type:
PROTEIN
Mol. Mass.:
16386.01
Organism:
Homo sapiens
Description:
ChEMBL_119916
Residue:
145
Sequence:
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
  
Inhibitor
Name:
BDBM50544440
Synonyms:
CHEMBL4647367 | US11192850, Entry 4t
Type:
Small organic molecule
Emp. Form.:
C17H9ClF3NO3
Mol. Mass.:
367.706
SMILES:
OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccc(cc1Cl)C(F)(F)F
Structure:
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