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Target
TAR DNA-binding protein 43
Ligand
BDBM50544712
Substrate
n/a
Meas. Tech.
ChEMBL_1993632 (CHEMBL4627527)
IC50
100±n/a nM
Citation
 Brown, DG; Shorter, J; Wobst, HJ Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
TAR DNA-binding protein 43
Synonyms:
TADBP_HUMAN | TAR DNA-binding protein 43 | TARDBP | TDP-43 | TDP43
Type:
PROTEIN
Mol. Mass.:
44737.83
Organism:
Homo sapiens
Description:
ChEMBL_105693
Residue:
414
Sequence:
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
  
Inhibitor
Name:
BDBM50544712
Synonyms:
CHEMBL4635203
Type:
Small organic molecule
Emp. Form.:
C24H31FN2O4
Mol. Mass.:
430.5123
SMILES:
COc1cc(NC(=O)CCC2CCCN(Cc3ccc(F)c(OC)c3)C2)cc(OC)c1
Structure:
Search PDB for entries with ligand similarity: