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Target
Type-1 angiotensin II receptor
Ligand
BDBM50544721
Substrate
n/a
Meas. Tech.
ChEMBL_1993677 (CHEMBL4627572)
EC50
>10000±n/a nM
Citation
 Narayanan, S; Vasukuttan, V; Rajagopal, S; Maitra, R; Runyon, SP Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50544721
Synonyms:
CHEMBL4644803
Type:
Small organic molecule
Emp. Form.:
C30H44N4O4
Mol. Mass.:
524.6948
SMILES:
CCCn1nc(cc1-c1c(OC)cccc1OC)C(=O)N[C@@H](CCC1CCCCC1)CC(=O)NC1CCC1 |r,wU:21.23,(9.06,-56.14,;9.67,-54.73,;8.76,-53.49,;9.38,-52.08,;10.89,-51.76,;11.04,-50.23,;9.64,-49.6,;8.61,-50.75,;7.07,-50.59,;6.45,-49.19,;7.35,-47.94,;6.72,-46.54,;4.92,-49.03,;4.01,-50.27,;4.63,-51.68,;6.16,-51.85,;6.79,-53.26,;5.88,-54.5,;12.38,-49.45,;12.37,-47.91,;13.71,-50.22,;15.04,-49.45,;15.04,-47.91,;16.37,-47.14,;16.37,-45.6,;17.7,-44.83,;17.71,-43.3,;16.37,-42.52,;15.04,-43.29,;15.03,-44.84,;16.38,-50.22,;17.71,-49.44,;17.71,-47.9,;19.05,-50.21,;20.38,-49.44,;21.87,-49.84,;22.27,-48.35,;20.78,-47.95,)|
Structure:
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