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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50102133
Substrate
n/a
Meas. Tech.
ChEBML_156211
IC50
6700±n/a nM
Citation
 Bloomer, JC; Boyd, HF; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Pinto, IL; Rawlings, DA; Smith, SA; Stansfield, IG; Stanway, SJ; Taylor, MA; Theobald, CJ; Whittaker, CM 1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett 11:1925-9 (2001) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50102133
Synonyms:
2-(4-Fluoro-benzylsulfanyl)-1-[2-oxo-2-(3-oxo-4-phenyl-piperazin-1-yl)-ethyl]-5-pyrimidin-5-ylmethyl-1H-pyrimidin-4-one | CHEMBL58682
Type:
Small organic molecule
Emp. Form.:
C28H25FN6O3S
Mol. Mass.:
544.6
SMILES:
Fc1ccc(CSc2nc(=O)c(Cc3cncnc3)cn2CC(=O)N2CCN(C(=O)C2)c2ccccc2)cc1
Structure:
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