Reaction Details Report a problem with these data
Target
Alpha-synuclein
Ligand
BDBM50545092
Substrate
n/a
Meas. Tech.
ChEMBL_1994333 (CHEMBL4628228)
Kd
107±n/a nM
Citation
 Chen, YF; Bian, J; Zhang, P; Bu, LL; Shen, Y; Yu, WB; Lu, XH; Lin, X; Ye, DY; Wang, J; Chu, Y Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for ?-synuclein fibrils by SPR evaluation system. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM50545092
Synonyms:
CHEMBL4642469
Type:
Small organic molecule
Emp. Form.:
C24H20N2O
Mol. Mass.:
352.4284
SMILES:
O=C(\C=C\c1ccc(cc1)C#N)N(Cc1ccccc1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: