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Target
Proteinase-activated receptor 1
Ligand
BDBM50545231
Substrate
n/a
Meas. Tech.
ChEMBL_1994600 (CHEMBL4628495)
IC50
550±n/a nM
Citation
 Fan, M; Han, M; Xia, Y; Zhang, Y; Chu, Y; Bai, G; Li, W; Li, J; Zhao, L; He, Y; Ma, X; Duan, Z Design and synthesis of potent PAR-1 antagonists based on vorapaxar. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50545231
Synonyms:
CHEMBL4632907
Type:
Small organic molecule
Emp. Form.:
C29H34N2O4
Mol. Mass.:
474.5913
SMILES:
[H][C@@]12C[C@]3([H])C[C@@H](CC[C@@]3([H])[C@H](\C=C\c3ccc(cc3)-c3ccccn3)[C@]1([H])[C@@H](C)OC2=O)NC(=O)OCC |r|
Structure:
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