Reaction Details
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Calcium/calmodulin-dependent protein kinase type 1D
Ligand
BDBM50545586
Substrate
n/a
Meas. Tech.
ChEMBL_1995999 (CHEMBL4629894)
IC50
28±n/a nM
Citation
Fromont, C; Atzori, A; Kaur, D; Hashmi, L; Greco, G; Cabanillas, A; Nguyen, HV; Jones, DH; Garzón, M; Varela, A; Stevenson, B; Iacobini, GP; Lenoir, M; Rajesh, S; Box, C; Kumar, J; Grant, P; Novitskaya, V; Morgan, J; Sorrell, FJ; Redondo, C; Kramer, A; Harris, CJ; Leighton, B; Vickers, SP; Cheetham, SC; Kenyon, C; Grabowska, AM; Overduin, M; Berditchevski, F; Weston, CJ; Knapp, S; Fischer, PM; Butterworth, S Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity J Med Chem 63:6784-6801 (2020) [PubMed] Article More Info.:
Target
Name:
Calcium/calmodulin-dependent protein kinase type 1D
Synonyms:
CAMK1D | CAMKID | CaM kinase I delta | KCC1D_HUMAN
Type:
PROTEIN
Mol. Mass.:
42916.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586559
Residue:
385
Sequence:
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK
Inhibitor
Name:
BDBM50545586
Synonyms:
CHEMBL4632457 | US11530193, Example 106
Type:
Small organic molecule
Emp. Form.:
C21H30N6O3S
Mol. Mass.:
446.566
SMILES:
CC(C)(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)S(C)(=O)=O |r|
Structure:
