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Target
Dual specificity mitogen-activated protein kinase kinase 5
Ligand
BDBM6511
Substrate
n/a
Meas. Tech.
ChEMBL_2014137 (CHEMBL4667715)
Kd
430±n/a nM
Citation
 Asquith, CRM; Treiber, DK; Zuercher, WJ Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK). Bioorg Med Chem Lett 29:1727-1731 (2019) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 5
Synonyms:
MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK5 | MKK5 | MP2K5_HUMAN | PRKMK5
Type:
PROTEIN
Mol. Mass.:
50110.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1495740
Residue:
448
Sequence:
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP
  
Inhibitor
Name:
BDBM6511
Synonyms:
4-Anilinoquinoline deriv. 8 | 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C20H22N2O5
Mol. Mass.:
370.3991
SMILES:
COc1cc(Nc2ccnc3cc(OC)c(OC)cc23)cc(OC)c1OC
Structure:
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