Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50546140
Substrate
n/a
Meas. Tech.
ChEMBL_2014464 (CHEMBL4668042)
EC50
16000±n/a nM
Citation
 Degorce, SL; Bodnarchuk, MS; Scott, JS Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a log ACS Med Chem Lett 10:1198-1204 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50546140
Synonyms:
CHEMBL4782474
Type:
Small organic molecule
Emp. Form.:
C21H24N6O3
Mol. Mass.:
408.4537
SMILES:
CC(C)(C)OC(=O)N1CC2(C1)CN(C2)c1ncc(OCc2ccncc2C#N)cn1
Structure:
Search PDB for entries with ligand similarity: