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Target
Neutrophil collagenase
Ligand
BDBM50104708
Substrate
n/a
Meas. Tech.
ChEMBL_105197 (CHEMBL713836)
Ki
180±n/a nM
Citation
 Schröder, J; Henke, A; Wenzel, H; Brandstetter, H; Stammler, HG; Stammler, A; Pfeiffer, WD; Tschesche, H Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. J Med Chem 44:3231-43 (2001) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50104708
Synonyms:
(S)-N-(5-(4-methoxyphenyl)-6H-1,3,4-thiadiazin-2-yl)-2-(phenylsulfonamido)propanamide | 2-Benzenesulfonylamino-N-[5-(4-methoxy-phenyl)-6H-[1,3,4]thiadiazin-2-yl]-propionamide | CHEMBL419750
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4S2
Mol. Mass.:
432.516
SMILES:
COc1ccc(cc1)C1=NN=C(NC(=O)[C@H](C)NS(=O)(=O)c2ccccc2)SC1 |t:9,11|
Structure:
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