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Target
E-selectin
Ligand
BDBM50105221
Substrate
n/a
Meas. Tech.
ChEMBL_199699 (CHEMBL802927)
IC50
30±n/a nM
Citation
 Zhu, GD; Arendsen, DL; Gunawardana, IW; Boyd, SA; Stewart, AO; Fry, DG; Cool, BL; Kifle, L; Schaefer, V; Meuth, J; Marsh, KC; Kempf-Grote, AJ; Kilgannon, P; Gallatin, WM; Okasinski, GF Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem 44:3469-87 (2001) [PubMed]  Article 
Target
Name:
E-selectin
Synonyms:
ELAM1 | LYAM2_HUMAN | SELE | Selectin | Selectin E
Type:
PROTEIN
Mol. Mass.:
66642.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1438995
Residue:
610
Sequence:
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL
  
Inhibitor
Name:
BDBM50105221
Synonyms:
4-(4-Ethyl-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL119732
Type:
Small organic molecule
Emp. Form.:
C16H14N2O2S
Mol. Mass.:
298.36
SMILES:
CCc1ccc(Oc2cncc3sc(cc23)C(N)=O)cc1
Structure:
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