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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50546402
Substrate
n/a
Meas. Tech.
ChEMBL_2015641 (CHEMBL4669219)
IC50
0.098000±n/a nM
Citation
 Kawatkar, SP; Barlaam, B; Kemmitt, P; Simpson, I; Watson, D; Wang, P; Lamont, S; Su, Q; Boiko, S; Ikeda, T; Patel, J; Pike, A; Pollard, H; Read, J; Sarkar, U; Wang, H; Wen, Q; Yan, Z; Dowling, JE; Dry, H; Edmondson, SD Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50546402
Synonyms:
CHEMBL4762995
Type:
Small organic molecule
Emp. Form.:
C25H25N9O
Mol. Mass.:
467.5257
SMILES:
CN(C)Cc1cn(nc1C)-c1ccnc2[nH]c(nc12)-c1cn(C)c2ccc(cc12)-c1nnc(C)o1
Structure:
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