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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50547282
Substrate
n/a
Meas. Tech.
ChEMBL_2017407 (CHEMBL4670985)
Kd
3.2±n/a nM
Citation
 Konieczny, M; Musielak, B; Kocik, J; Skalniak, L; Sala, D; Czub, M; Magiera-Mularz, K; Rodriguez, I; Myrcha, M; Stec, M; Siedlar, M; Holak, TA; Plewka, J Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint. J Med Chem 63:11271-11285 (2020) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50547282
Synonyms:
CHEMBL4765124
Type:
Small organic molecule
Emp. Form.:
C26H26BrNO3
Mol. Mass.:
480.394
SMILES:
OC(=O)[C@@H]1CCCCN1Cc1ccc(OCc2cccc(c2Br)-c2ccccc2)cc1 |r|
Structure:
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