Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B7
Ligand
BDBM50049730
Substrate
n/a
Meas. Tech.
ChEMBL_2018933 (CHEMBL4672511)
IC50
1198±n/a nM
Citation
 Chen, H; Zhang, X; Zhang, X; Fan, Z; Liu, W; Lei, Y; Zhu, C; Ma, B Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B7
Synonyms:
Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1 | ALD1_RAT | Akr1b7 | Akr1b14
Type:
PROTEIN
Mol. Mass.:
36127.39
Organism:
Rat
Description:
ChEMBL_109605
Residue:
316
Sequence:
MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY
  
Inhibitor
Name:
BDBM50049730
Synonyms:
Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid | CHEMBL56337
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: