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Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50106252
Substrate
n/a
Meas. Tech.
ChEMBL_1708 (CHEMBL616915)
Ki
180±n/a nM
Citation
 Russell, MG; Baker, RJ; Barden, L; Beer, MS; Bristow, L; Broughton, HB; Knowles, M; McAllister, G; Patel, S; Castro, JL N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands. J Med Chem 44:3881-95 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50106252
Synonyms:
CHEMBL263700 | [3-(2-Dimethylamino-ethyl)-5-hydroxy-indol-1-yl]-phenyl-methanone
Type:
Small organic molecule
Emp. Form.:
C19H20N2O2
Mol. Mass.:
308.3743
SMILES:
CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12
Structure:
Search PDB for entries with ligand similarity: