Reaction Details Report a problem with these data
Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM50547900
Substrate
n/a
Meas. Tech.
ChEMBL_2019386 (CHEMBL4672964)
IC50
18±n/a nM
Citation
 Blass, BE Novel Potassium Channel Inhibitors. ACS Med Chem Lett 11:2357-2358 (2020) [PubMed]  Article 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM50547900
Synonyms:
CHEMBL4756080 | US20240034717, Example 31.47
Type:
Small organic molecule
Emp. Form.:
C18H25F3N2
Mol. Mass.:
326.3997
SMILES:
CC(C)(N)CN(C1CCC1)C1(CC1)c1cccc(c1)C(F)(F)F
Structure:
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