Reaction Details Report a problem with these data
Target
Arginase-2, mitochondrial
Ligand
BDBM50547932
Substrate
n/a
Meas. Tech.
ChEMBL_2019399 (CHEMBL4672977)
IC50
24±n/a nM
Citation
 Sabnis, RW Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases. ACS Med Chem Lett 11:2370-2371 (2020) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50547932
Synonyms:
CHEMBL4778086
Type:
Small organic molecule
Emp. Form.:
C15H30BN3O5
Mol. Mass.:
343.227
SMILES:
CC(C)[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O |r|
Structure:
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