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Target
Ghrelin O-acyltransferase
Ligand
BDBM50548065
Substrate
n/a
Meas. Tech.
ChEMBL_2019855 (CHEMBL4673668)
IC50
1.7±n/a nM
Citation
 Iyer, MR; Wood, CM; Kunos, G Recent progress in the discovery of ghrelin  RSC Med Chem 11:1136-1144 (2020) [PubMed]  Article 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM50548065
Synonyms:
CHEMBL4785875
Type:
Small organic molecule
Emp. Form.:
C18H12Cl2F3NO3S
Mol. Mass.:
450.259
SMILES:
Cc1nc(ccc1COc1cc(Cl)c2cc(CC(O)=O)sc2c1Cl)C(F)(F)F
Structure:
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