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Target
Splicing factor 45
Ligand
BDBM50548170
Substrate
n/a
Meas. Tech.
ChEMBL_2020029 (CHEMBL4673842)
Kd
960±n/a nM
Citation
 Jagtap, PK; Garg, D; Kapp, TG; Will, CL; Demmer, O; Lührmann, R; Kessler, H; Sattler, M Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing. J Med Chem 59:10190-10197 (2016) [PubMed]  Article 
Target
Name:
Splicing factor 45
Synonyms:
45 kDa-splicing factor | RBM17 | RNA-binding motif protein 17 | SPF45 | SPF45_HUMAN | Splicing factor 45
Type:
PROTEIN
Mol. Mass.:
44957.98
Organism:
Homo sapiens
Description:
ChEMBL_120106
Residue:
401
Sequence:
MSLYDDLGVETSDSKTEGWSKNFKLLQSQLQVKKAALTQAKSQRTKQSTVLAPVIDLKRGGSSDDRQIVDTPPHVAAGLKDPVPSGFSAGEVLIPLADEYDPMFPNDYEKVVKRQREERQRQRELERQKEIEEREKRRKDRHEASGFARRPDPDSDEDEDYERERRKRSMGGAAIAPPTSLVEKDKELPRDFPYEEDSRPRSQSSKAAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKIIVGDATEKDASKKSDSNPLTEILKCPTKVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPDDEAVRIFLEFERVESAIKAVVDLNGRYFGGRVVKACFYNLDKFRVLDLAEQV
  
Inhibitor
Name:
BDBM50548170
Synonyms:
CHEMBL4799705
Type:
Small organic molecule
Emp. Form.:
C41H58N14O12
Mol. Mass.:
938.9858
SMILES:
N[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O |r|
Structure:
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