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Target
Matrix metalloproteinase-9
Ligand
BDBM50107582
Substrate
n/a
Meas. Tech.
ChEBML_105370
Ki
277±n/a nM
Citation
 Yao, W; Chao, M; Wasserman, ZR; Liu, RQ; Covington, MB; Newton, R; Christ, D; Wexler, RR; Decicco, CP Potent P1' biphenylmethyl substituted aggrecanase inhibitors. Bioorg Med Chem Lett 12:101-4 (2001) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-9
Synonyms:
67 kDa matrix metalloproteinase-9 | 82 kDa matrix metalloproteinase-9 | 92 kDa gelatinase | 92 kDa type IV collagenase | CLG4B | GELB | Gelatinase B | MMP-9 | MMP9 | MMP9_HUMAN | Matrix metalloproteinase 9 (MMP-9) | Matrix metalloproteinase-9 (MMP-9) | Matrix metalloproteinase-9 (MMP9)
Type:
Enzyme
Mol. Mass.:
78452.28
Organism:
Homo sapiens (Human)
Description:
P14780
Residue:
707
Sequence:
MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
  
Inhibitor
Name:
BDBM50107582
Synonyms:
(R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-succinamide | CHEMBL268680
Type:
Small organic molecule
Emp. Form.:
C27H26N6O4
Mol. Mass.:
498.5331
SMILES:
ONC(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
Structure:
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